Hydroboration (Brown, Herbert C.)

Oxygen-Directed Intramolecular Hydroboration

Metal-free homoallylic oxygen-directed intramolecular hydroboration is reported. Regioselectivities from 20:1 to 82:1 favoring the 1,3-dioxy-substituted products have been achieved using Me2S.BH3/TfOH followed by standard oxidative workup. Branching at the C5 position improves regioselectivity.

Magnesium-catalysed nitrile hydroboration

A b-diketiminato n-butylmagnesium complex is presented as a selective precatalyst for the reductive hydroboration of organic nitriles with pinacolborane (HBpin). Stoichiometric reactivity studies indicate that catalytic turnover ensues through the generation of magnesium aldimido, aldimidoborate and borylamido intermediates, which are formed in a sequence of intramolecular nitrile insertion and...

Statement - C . Titus Brown

The future of biology and biomedicine lies at the intersection of data gathering, hypothesis generation, and hypothesis testing. It is increasingly easy to gather large amounts of relevant data, but interpretation of that data and connection of that data to downstream hypothesis-driven experimentation is still difficult and rare. Effectively integrating large scale data analysis with “wet” biol...

Masiuk, Chen-Feng Qi and Herbert C. Morse III

Herbert Thoms

The eventful chapters of contemporaneous medical history in Connecticut have not yet received the historian's scrutiny and are still only records scattered here and there in organization archives and miscellaneous correspondence. Many of us have been a part of these events and as participants are poorly qualified to place values on them. As in all history, one must await the developing vista of...